吲达帕胺与双氢克尿噻治疗高血压的疗效及安全性

The effect and safety of indapamide and hydrochlorothiazide in treating hypertension

目的探讨研究吲达帕胺与双氢克尿噻治疗高血压的临床疗效及安全性。方法选取神池县中医院2011年1月—2014年1月收治的符合要求的高血压患者200例,采用随机数字表法分为观察组和对照组,每组100例。对照组患者给予双氢克尿噻治疗,观察组患者给予吲达帕胺治疗。比较两组患者治疗前后血压、实验室检查指标及不良反应发生情况。结果治疗前两组患者收缩压及舒张压比较,差异无统计学意义(P>0.05);治疗后两组患者舒张压与收缩压比较,差异无统计学意义(P>0.05)。治疗前两组患者实验室检查指标比较,差异无统计学意义(P>0.05);治疗后对照组患者血钾低于观察组,差异有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论吲达帕胺治疗高血压的临床疗效确切,且不良反应少。

Objective To study the effect and safety of indapamide and hydrochlorothiazide in treating hypertension.Methods A total of 200 hypertension patients were selected in the Traditional Chinese Medicine Hospital of Shenchi County from January 2011 to January 2014,which were divided into control group and observation group by random number table method,100 cases in each. The control group was treated with hydrochlorothiazide,the observation group was treated with indapamide. Before and after treatment blood pressure,laboratory inspection index and occurrence of adverse reactions between the two groups were compared. Results Before treatment systolic blood pressure and diastolic blood pressure between the two groups showed no significant differences( P > 0. 05); after treatment systolic blood pressure and diastolic blood pressure between the two groups showed no significant differences( P > 0. 05). Before treatment laboratory inspection index between the two groups showed no significant differences( P > 0. 05); after treatment serum potassium of the control group was lower than observation group( P < 0. 05). In the observation group,occurrence rate of adverse reaction was lower than control group( P < 0. 05).Conclusion The effect of indapamide is sure in the treatment of hypertension,it has less adverse reactions and high safty.