中医内外合治法治疗湿热型儿童单纯性肾病综合征的临床疗效

The curative effect of traditional Chinese medicine and external in treating damp heat type of children with simple nephrotic syndrome

目的探讨中医内外合治法治疗湿热型儿童单纯性肾病综合征的临床疗效。方法选取泸州医学院附属中医院儿科2012年10月—2014年6月收治的湿热型单纯性肾病综合征患儿90例,随机将所有患儿分为对照组和治疗组,各45例。两组患儿均给予常规治疗,在此基础上对照组患儿采用单纯内治法,治疗组患儿采用中医内外合治法治疗,比较两组患儿的临床疗效、治疗前后实验室血清指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清总蛋白(TP)]、治疗前后24h尿中微量总蛋白及24h尿蛋白定量。结果治疗组患儿治疗总有效率为95.6%,高于对照组的77.8%,差异有统计学意义(P<0.05)。治疗前,两组患儿血清TG、TC、HDL-C、LDL-C、TP比较,差异无统计学意义(P>0.05)。治疗后,治疗组患儿血清TG、TC、LDL-C低于对照组,TP高于对照组,差异有统计学意义(P<0.05);两组患儿HDL-C比较,差异无统计学意义(P>0.05)。治疗后两组患儿血清TG、TC、LDL-C低于治疗前,TP高于治疗前,差异有统计学意义(P<0.05)。治疗前,两组患儿24h尿中微量总蛋白、24h尿蛋白定量比较,差异无统计学意义(P>0.05)。治疗后,治疗组患儿24h尿中微量总蛋白、24h尿蛋白定量低于对照组,差异有统计学意义(P<0.05)。结论中医内外治合法可有效治疗湿热型儿童单纯性肾病综合征,改善患儿临床症状。

Objective To investigate the clinical efficacy of traditional Chinese medicine and external in treating damp heat type of children with simple nephrotic syndrome. Methods From October 2012 to June 2014 in Luzhou Medical College Affiliated Hospital 90 damp heat type of children with simple nephrotic syndrome were selected,all patients were randomly divided into control group and treatment group,45 cases in each. Two groups were given conventional treatment,on the basis of it the control group were used only internal treatment,the treatment group were treated with traditional Chinese medicine and external,the clinical efficacy,before and after treatment serum laboratory indexes three triglyceride( TG), total cholesterol( TC),high density lipoprotein cholesterol( HDL- C),low density lipoprotein cholesterol( LDL- C),serum total protein( TP),micro total protein and 24 h urinary protein were measured before and after treatment in 24 h of two groups were compare.Results The total effective rate of treatment group was 95. 6%,which was higher than 77. 8% of the control group( P <0. 05). Before treatment,serum TG,TC,HDL- C,LDL- C,TP between the two groups showed no significant differences( P > 0. 05). After treatment serum TG,TC,LDL- C of the treatment group were lower than the control group,TP was higher than the control group( P < 0. 05); HDL- C between the two groups showed no significant differences( P > 0. 05). After treatment serum TG,TC,LDL- C of the two groups were lower than before treatment,TP was higher than before treatment( P< 0. 05). Before treatment,24 h trace protein in urine,24 h urinary protein between the two groups showed no significant differences( P > 0. 05). After treatment,24 h urine trace protein in urine,24 h protein quantitation of the treatment group were lower than the control group( P < 0. 05). Conclusion Internal and external treatment of traditional Chinese medicine can be effective treating children with simple nephrotic syndrome,and improve the clinical symptoms.