特布他林联合硫酸镁雾化吸入治疗小儿哮喘的临床疗效观察

Clinical effect of terbutaline combined with magnesium sulfate aerosol inhalation in treating children asthma

目的探讨特布他林联合硫酸镁雾化吸入治疗小儿哮喘的临床疗效。方法选取2013年10月—2015年3月内江市疾病预防控制中心儿科收治的哮喘患儿104例,按照双盲随机法将患儿分为对照组与试验组,各52例。在对症治疗基础上对照组给予特布他林雾化吸入治疗,试验组给予特布他林联合硫酸镁雾化吸入治疗。比较两组患儿临床疗效、咳喘消失时间、湿啰音消失时间、住院时间及呼气峰值流速、不良反应发生情况。结果试验组患儿总好转率高于对照组,差异有统计学意义(P<0.05)。试验组患儿咳喘消失时间、湿啰音消失时间、住院时间短于对照组,呼气峰值流速高于对照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论特布他林联合硫酸镁雾化吸入治疗小儿哮喘的临床疗效确切,有助于改善患儿的临床症状与肺功能,且安全性高。

Objective To study the clinical effect of terbutaline combined with magnesium sulfate aerosol inhalation in treating children asthma. Methods From October 2013 to March 2015 in the Center for Disease Control and Prevention of Neijiang City 104 asthma children were selected,referring to random double blind method the children were divided into the control group and the experiment group,52 cases in each group. Based on implement symptomatic treatment the control group were treated with terbutaline atomization inhalation,the experiment group were treated with terbutaline combined with magnesium sulfate aerosol inhalation. Curative effect,extinction time of cough and asthma,extinction time of moist sounds,hospital stays,peak expiratory flow and adverse reactions of two groups were comparred. Results In the experiment group,the total improvement rate was higher than control group( P < 0. 05); extinction time of cough and asthma,extinction time of moist sounds,hospital stays were shorter than control group,peak expiratory flow was higher than control group( P < 0. 05). Occurrence rate of adverse reactions between the two groups showed no significant differences( P > 0. 05). Conclusion Terbutaline combined with magnesium sulfate aerosol inhalation have exact effect in treating children asthma,can rapidly improve the clinical symptoms and pulmonary function of children,have high safety.