DA与IA方案治疗成人初治急性髓系白血病的疗效研究

Effect of DA and IA regimen in the treatment of adult patients with acute myelogenous leukemia

目的比较DA与IA方案治疗成人初治急性髓系白血病的疗效。方法选取2013年2月—2015年3月贵州省人民医院诊断为初治急性髓系白血病的成年患者100例,随机分为研究组和对照组,各50例。研究组接受去甲氧柔红霉素+阿糖胞苷巩固治疗,对照组接受柔红霉素+阿糖胞苷巩固治疗。比较两组中性粒细胞恢复时间、治疗期间白细胞最低值、临床疗效、治疗后1年无病生存率。结果研究组中性粒细胞恢复时间短于对照组,治疗期间白细胞最低值高于对照组,总有效率高于对照组,1年无病生存率高于对照组,差异有统计学意义(P<0.05)。结论IA方案治疗急性髓系白血病的疗效优于DA方案,患者诱导期间骨髓抑制轻,生存期长。

Objective To compare the effect of DA and IA regimen in the treatment of adult patients with acute myelogenous leukemia. Methods From February 2013 to March 2015 in the People' s Hospital of Guizhou Province 100 patients diagnosis for early treatment acute myelogenous leukemia were selected,they were randomly divided into 50 cases of study group and 50 cases of control group,the study group received to idarubicin plus cytarabine consolidation therapy,the control group received daunorubicin and cytarabine consolidation therapy. Neutrophil recovery time, the minimum value of white blood cell,effect,after treatment for 1 years disease-free survival rate between the two groups were compared. Results There were significant differences in the neutrophil recovery time and the lowest value of leukocyte between the study group and the control group( P < 0. 05). The total effetive rate,after treatment for 1 years disease-free survival rate of the study group were higher than the control group( P < 0. 05). Conclusion The effect of IA regimen in the treatment of adult patients with acute myelogenous leukemia is better than the DA regimen,patients with bone marrow suppression during the induction period of light,have long lifetime.