氟比洛芬酯与阿片类镇痛药在患者术后疼痛镇痛中的应用效果及安全性研究

The application effect and safety of flurbiprofen and opioid analgesics in postoperative

目的探讨氟比洛芬酯与阿片类镇痛药在患者术后疼痛镇痛中的应用效果及安全性。方法选取2015年1月—2016年1月遂宁市第三人民医院收治的手术患者85例,随机将患者分成甲组43例与乙组42例。甲组以氟比洛芬酯为主要麻醉药物,乙组则以芬太尼为主要麻醉药物,比较两组患者不同时间点的疼痛程度、镇痛优良率、不良反应发生率。结果甲组患者术后1、3、6、12、24h的VAS疼痛评分低于乙组,差异有统计学意义(P<0.05)。甲组患者镇痛优良率高于乙组,差异有统计学意义(P<0.05)。甲组患者不良反应发生率低于乙组,差异有统计学意义(P<0.05)。结论与阿片类镇痛药物相比,氟比洛芬酯在患者术后疼痛镇痛中的应用效果更佳,且不良反应少。

Objective To study the effect and safety of flurbiprofen and opioid analgesics in postoperative. Methods From January 2015 to January 2016 in the Third People's Hospital of Suining surgery patients 85 cases were selected,patients were randomly divided into 43 cases in group A and 42 cases in group B. Group A with flurbiprofen as the main anesthetic drugs,group B with fentanyl as the main anesthetic drugs,the degree of pain were compared between the two groups at different time points,the excellent rate of analgesia,the incidence of adverse reactions were compared between the two groups. Results Postoperative 1,3,6,12,24 h VAS pain score of group A were lower than group B,the differences were statistically significant( P < 0. 05). The excellent rate of analgesia in group A was higher than group B,the difference was statistically significant( P < 0. 05). The adverse reaction rate of group A was lower than that of group B,the difference was statistically significant( P< 0. 05). Conclusion Compared with opioid analgesics,application effect of flurbiprofen on postoperative analgesia in patients is better,and has less adverse reaction.