福辛普利、螺内酯及美托洛尔治疗左心室射血分数降低慢性心力衰竭的临床疗效研究

Clinical effect of fosinopril,spironolactone and metoprolol in the treatment of chronic heart failure with lower left ventricular ejection fraction

目的探讨福辛普利、螺内酯及美托洛尔治疗左心室射血分数降低慢性心力衰竭的临床疗效。方法选取2014年10月—2015年10月于兴业县人民医院收治的124例左心室射血分数降低慢性心力衰竭患者,按照随机数字表法分为对照组与试验组,各62例。两组患者均给予对症治疗,对照组在此基础上给予螺内酯、美托洛尔治疗,试验组在对照组基础上加用福辛普利钠片治疗。比较两组患者临床疗效、6min步行试验、B型脑钠肽、左心室射血分数、左心室舒张末期内径、左心室收缩末期内径,并观察两组患者不良反应发生情况。结果试验组患者总有效率高于对照组(P<0.05)。试验组患者6min步行试验长于对照组,B型脑钠肽水平低于对照组,左心室射血分数高于对照组,左心室舒张末期内径、左心室收缩末期内径小于对照组,不良反应发生率低于对照组(P<0.05)。结论福辛普利、螺内酯及美托洛尔联合治疗左心室射血分数降低慢性心力衰竭的临床疗效确切,可改善患者心功能指标,且不良反应少。

Objective To discuss the clinical effect of fosinopril,spironolactone and metoprolol in the treatment of chronic heart failure with lower left ventricular ejection fraction. Methods A total of 124 cases of chronic heart failure with lower left ventricular ejection fraction patients were selected from October 2014 to October 2015 in People's Hospital of Xingye County,which were divided into control group and experimental group,62 cases in each group. Two groups of patients were given symptomatic treatment,the control group was given spironolactone + metoprolol treatment,experimental group was given fosinopril sodium tablets based on control group. The clinical effect,6min walking test,B-type natriuretic peptide and left ventricular ejection fraction,left ventricular end diastolic diameter,left ventricular end systolic diameter were compared between the two groups,and the incidence of adverse reactions were observed between the two groups of patients. Results The total effective rate of experimental group was higher than that of the control group( P < 0. 05). The experimental group of 6min walking test was longer than control group,B-type brain natriuretic peptide level was lower than control group,left ventricular ejection fraction was higher than control group,the left ventricular end diastolic diameter and left ventricular end systolic diameter were less than those of control group,and the incidence of adverse reactions were lower than control group( P < 0. 05). Conclusion The clinical effect of fosinopril,spironolactone and metoprolol in the treatment of chronic heart failure with lower left ventricular ejection fraction is exact,can improve the heart function index of patients,and with less adverse reactions.