PCOS患者卵巢过度刺激综合征与血清抗苗勒管激素的关系

Relationship between ovarian hyperstimulation syndrome and serum anti-mullerian hormone in patients with PCOS

目的分析多囊卵巢综合征(PCOS)患者血清抗苗勒管激素(AMH)水平与卵巢过度刺激综合征(OHSS)的关系。方法选取2017年1月-2018年6月医院收治的PCOS患者66例,均行第一周期常规长方案体外授精胚胎移植(IVF-ET)治疗,根据是否发生OHSS分为OHSS组32例及未发生OHSS组34例,比较2组基础血清AMH水平及降调后血清AMH水平。结果 OHSS组患者基础血清AMH水平及降调后AMH水平均高于未发生OHSS组,差异均有统计学意义(P<0.05)。PCOS患者基础血清AMH水平与HCG日E_2水平及大卵泡数呈显著正相关(r=0.255,r=0.345,P<0.05)。结论 COS患者血清AMH水平与OHSS呈显著相关性,可能成为临床预测OHSS的新指标。

Objective To analyze the relationship between serum anti-mullerian hormone(AMH) level and ovarian hyperstimulation syndrome(OHSS) in patients with polycystic ovary syndrome(PCOS).Methods 66 patients with PCOS admitted to the hospital from January to February 2018 were selected,all patients in the first period received long-term and in vitro fertilization and embryo transfer(IVF-ET) treatment.According to whether OHSS occurs,they were divided into OHSS group(32 cases) and non-OHSS group(34 cases),the levels of baseline serum AMH and downregulated serum AMH of the two groups were compared.Results The levels of baseline serum AMH and downregulated serum AMH of the OHSS group were higher than those in the non-OHSS group(P<0.05).The baseline serum AMH level of PCOS patients was significantly positively correlated with HCG day E2 level and large follicle number(r=0.255,r=0.345,P<0.05).Conclusion The serum AMH levels have an obvious correlation with OHSS,which it may be considered as the new prediction indicator of OHSS.