哌拉西林钠舒巴坦钠治疗小儿肺炎的临床疗效及安全性

Clinical efficacy and safety of Piperacillin sodium and sulbactam sodium in the treatment of children with pneumonia

目的观察注射用哌拉西林钠舒巴坦钠(4∶1)治疗小儿肺炎的治疗效果及安全性。方法选择医院2016年1月-2017年12月收治的小儿肺炎患儿180例,按照治疗方法不同分为3组各60例。A组给予头孢西丁治疗,B组给予拉氧头孢治疗,C组给予哌拉西林钠舒巴坦钠治疗,比较3组临床疗效、热退时间、咳嗽消失时间、肺部啰音消退时间、血象恢复时间、细菌清除情况及不良反应。结果 C组总有效率、细菌清除率高于A组和B组,C组患儿热退时间短于A组和B组,差异均有统计学意义(P<0.05)。3组咳嗽消失时间、肺部啰音消退时间、血象恢复时间及不良反应发生率比较差异均无统计学意义(P>0.05)。结论哌拉西林钠舒巴坦钠治疗小儿肺炎具有安全、有效的特点,且无不良反应发生率低。

Objective To observe the therapeutic effect and safety of piperacillin sodium and sulbactam sodium for injection(4:1) in the treatment of children with pneumonia.Methods 180 children with pediatric pneumonia admitted to the hospital from January 2016 to December 2017 were selected,according to the different treatment methods,they were divided into 3 groups,60 cases in each group.The group A was given cefoxitin treatment,the group B was given oxycephalosporin treatment,the group C was given piperacillin sodium and sulbactam sodium.The clinical efficacy,heat withdrawal time,cough disappearance time,lung vocal regression time,blood loss recovery time,bacterial clearance and adverse reactions were compared between the three groups.Results The total effective rate and bacterial clearance rate of group C were higher than those of group A and group B,the heat withdrawal time of group C was shorter than those of group A and group B,and the differences were statistically significant(P<0.05).There were no significant differences in the disappearance time of cough,the time of lung voice disappearance,the recovery time of blood picture and the incidence of adverse reactions in the three groups(P>0.05).Conclusion Piperacillin sodium and sulbactam sodium is safe and effective in the treatment of children with pneumonia,and the incidence of no adverse reactions is low.