双相情感障碍治疗前后血清尿酸水平研究

Study on serum uric acid level before and after treatment of bipolar affective disorder

目的探讨双相情感障碍(BD)不同临床相及治疗前后血清尿酸(UA)水平差异。方法选取2016年5月-2017年12月医院收治的BD患者180例(躁狂发作90例,抑郁发作67例,混合发作23例),比较BD患者不同临床相及治疗前后血清UA水平差异。结果 BD躁狂发作患者治疗前后血清尿酸UA水平均高于BD抑郁发作患者(P=0. 029,P=0. 036);治疗后BD各临床相血清UA水平较治疗前均下降(P <0. 05)。结论 BD躁狂发作患者UA水平高于BD抑郁发作患者; BD各临床相症状改善后UA水平下降。

Objective To explore the different clinical phases of bipolar affective disorder(BD)and the difference of serum uric acid(UA)levels before and after treatment.Methods 180 BD patients(90 manic episodes,67 depressive episodes and 23 mixed episodes)were selected from May 2016 to December 2017.To compare the different clinical phases of BD patients and the difference of serum UA level before and after treatment.Results The serum uric acid UA level in patients with BD manic episode before and after treatment was higher than that in patients with BD depressive episode(P=0.029,P=0.036).After treatment,the serum UA levels in all clinical phases of BD decreased compared with those before treatment(P<0.05).Conclusion UA level in patients with manic episode of BD was higher than that in patients with depressive episode of BD.UA level decreased after improvement of clinical phases of BD.