肠内营养乳剂对ICU机械通气危重患者的应用效果分析

Effect of TPF on critical patients with mechanical ventilation in ICU

目的观察肠内营养乳剂(瑞先)在ICU机械通气患者早期肠内营养(EN)治疗中的效果应用。方法180例患者随机分为EN组和对照组,每组90例。比较2组治疗前后营养指标和生化指标变化,并记录并发症(如反流、呕吐、腹胀、腹泻等)发生情况。结果 (1)支持后,EN组血清总蛋白(TP)、血清白蛋白(ALB)较支持前有所增高(P <0. 01); EN组血清前白蛋白(PA)、血红蛋白(Hb)支持前后差异无统计学意义(P> 0. 05);对照组TP、ALB、PA较支持前有所下降(P <0. 01或P <0. 05),Hb支持前后比较差异无统计学意义(P> 0. 05);(2) EN组和对照组经营养支持后,肌酐(Cr)、谷丙转氨酶(ALT)、三酰甘油(TG)、尿素氮(UN)、血糖(Glu)与支持治疗前比较差异无统计学(P> 0. 05);(3) EN组并发症的发生率低于对照组,差异有统计学意义(P <0. 05)。结论 ICU机械通气患者给予瑞先支持治疗能有效改善机体营养状态并减少胃肠道并发症。

Objective To observe the effect of TPF on critical patients with mechanical ventilation in ICU.Methods One hundred and eighty patients were randomly divided into EN group and control group,90 cases in each group.The changes of nutritional and biochemical indexes before and after treatment were compared between the two groups,and the occurrence of complications(such as reflux,vomiting,abdominal distension,diarrhea,etc.)was recorded.Results After treatment,the levels of TP and ALB in EN group were higher than those before treatment(P<0.01).There was no significant difference in PA and Hb before and after treatment in EN group(P>0.05).The levels of TP,ALB and PA in the control group were lower than those before treatment(P<0.01 or P<0.05),but there was no significant difference in Hb before and after treatment(P>0.05).There was no significant difference in Cr,ALT,TG,UN and Glu between EN group and control group before and after treatment(P>0.05).The incidence of complications in EN group was lower than that in control group(P<0.05).Conclusion TPF can effectively improve the nutritional status of patients with mechanical ventilation in ICU and reduce the incidence of gastrointestinal complications.