丙氨酰谷氨酰胺联合肠外营养治疗严重多发伤的临床效果观察

Clinical effect of alanyl glutamine combined with parenteral nutrition in the treatment of severe multiple injuries

目的观察严重多发伤患者治疗中应用丙氨酰谷氨酰胺联合肠外营养的效果。方法选择医院收治的严重多发伤患者78例纳入此次研究,随机分为观察组和对照组,每组39例。对照组接受临床常规治疗以及肠外营养治疗,观察组在此基础上联合丙氨酰谷氨酰胺治疗。比较2组治疗前后血清水平变化情况、机械通气时间及住ICU时间。结果治疗后,2组血清白蛋白、血清前白蛋白水平较治疗前均升高,且观察组上述指标升高幅度大于对照组(P均<0. 01);观察组机械通气时间、住ICU时间短于对照组,差异有统计学意义(P <0. 01)。结论针对严重多发伤患者实施肠外营养与丙氨酰谷氨酰胺联合治疗,其临床效果显著,可全面改善患者血清水平,缩短患者临床治疗时间。

Objective To observe the clinical effect of alanyl glutamine combined with parenteral nutrition in the treatment of severe multiple injuries.Methods Seventy-eight patients with severe multiple injuries were randomly divided into observation group and control group,39 cases in each group.The control group received routine treatment and parenteral nutrition treatment,while the observation group received alanyl glutamine treatment on the basis of the control group.The changes of serum level,mechanical ventilation time and ICU hospitalization time before and after treatment were compared between the two groups.Results After treatment,the levels of serum albumin and prealbumin in the two groups were higher than those before treatment,and the increase in the observation group was greater than that in the control group(P<0.01).The duration of mechanical ventilation and ICU hospitalization in the observation group were shorter than those in the control group(P<0.01).Conclusion The clinical effect of alanyl glutamine combined with parenteral nutrition in the treatment of severe multiple injuries is remarkable.It can improve the serum level of patients comprehensively and shorten the clinical treatment time of patients.