短疗程抗菌药物治疗肝硬化合并原发性腹膜炎的临床疗效

Clinical effect of short-course antibiotics in treating cirrhosis complicated with primary peritonitis

目的探讨短疗程抗菌药物治疗肝硬化合并原发性腹膜炎的临床疗效。方法选取宣汉县人民医院2014年4月—2017年12月收治的肝硬化合并原发性腹膜炎患者180例,根据不同疗程分为参照组和试验组,各90例。两组患者均进行抗菌药物治疗,参照组患者治疗疗程10～14 d,试验组患者治疗疗程5～7 d。比较两组患者治疗48h或72 h应答率、治愈率、治疗1个月内存活率。结果两组患者治疗48 h或72 h应答率、治愈率、治疗1个月内存活率比较,差异无统计学意义(P>0.05)。结论短疗程抗菌药物治疗肝硬化合并原发性腹膜炎的临床疗效与长疗程治疗相当,均可有效改善患者临床症状及体征,且短期存活率较高,推荐采用短疗程治疗该疾病。

Objective To investigate the clinical effect of short-course antibiotics in treating cirrhosis complicated with primary peritonitis.Methods A total of 180 patients with cirrhosis complicated with primary peritonitis were selected from April 2014 to December 2017 in Xuanhan County People’s Hospital,which were divided into reference group and experimental group according to the course of treatment,90 cases in each group.Both groups were treated with antimicrobial drugs,the treatment course of control group was 10-14 days,and experimental group was 5-7 days.The response rate,cure rate and survival rate within 1 month were compared between the two groups.Results There was no significant differences in response rate,cure rate or within 1 month survival rate between the two groups(P>0.05).Conclusion Short-course antibiotic therapy has the same clinical effect as long-term treatment for cirrhosis complicated with primary peritonitis,which can effectively improve the clinical symptoms and signs of patients,and with higher short-term survival rate,so the short-course is recommeneed for treatment.