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丁苯酞软胶囊对帕金森痴呆患者炎性因子及认知功能的影响 被引量:13

Impact of butylphthalide soft capsule on inflammatory factors and cognitive function of Parkinson's dementia patients
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摘要 目的探讨丁苯酞软胶囊对帕金森痴呆(PDD)患者炎性因子及认知功能的影响。方法选取长沙市第三医院神经内科及门诊2015年3月—2018年3月收治的PDD患者94例,随机分为对照组和研究组,各47例。两组患者均采用常规药物治疗,研究组患者在常规治疗基础上加用丁苯酞软胶囊治疗,两组患者均持续治疗12周。比较两组患者治疗前后血清炎性因子〔血清胱抑素C(CysC)、C反应蛋白(CRP)、白介素1β(IL-1β)〕水平及帕金森病评定量表(UPDRS)、简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分,并观察两组患者不良反应发生情况。结果治疗前,两组患者血清CysC、CRP和IL-1β水平比较,差异无统计学意义(P>0.05);治疗后,研究组患者血清CysC、CRP和IL-1β水平低于对照组(P<0.05)。治疗前,两组患者UPDRS、MMSE、MoCA评分比较,差异无统计学意义(P>0.05);治疗后,研究组患者UPDRS评分低于对照组,MMSE、MoCA评分高于对照组(P<0.05)。两组患者均未出现严重不良反应。结论丁苯酞软胶囊可有效减轻PDD患者的炎性反应,保护神经功能,改善认知功能,且安全性高。 Objective To explore the impact of butylphthalide soft capsule on inflammatory factors and cognitive function of Parkinson’s dementia(PDD)patients.Methods A total of 94 cases of PDD patients were selected from March2015 to March 2018 in the Third Hospital of Changsha,which were randomly divided into control group and study group,47 cases in each group.All patients were treated with routine drugs,study group was given butylphthalide soft capsule,both groups were treated for 12 weeks.The serum levels of inflammatory factors(CysC,CRP,IL-1β)and UPDRS,MMSE,MoCA scores before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,no significant differences of serum levels of CysC,CRP or IL-1βwas found between the two groups(P>0.05);after treatment,the study group of serum levels of CysC,CRP,IL-1βwere lower than control group(P<0.05).Before treatment,no significant differences of UPDRS,MMSE or MoCA scores was found between the two groups(P>0.05);after treatment,the study group of UPDRS scores were lower than control group,MMSE and MoCA scores were higher than control group(P<0.05).No serious adverse reactions happened between the two groups.Conclusion Butylphthalide soft capsule can effectively reduce the inflammatory factors of patients,and protect neurologic function,improve cognitive function,and with high safety.
作者 丁玲 肖波 汤显靖 陈旭 黄芳 DING Ling;XIAO Bo;TANG Xian-jing(Department of Neurology,the Third Hospital of Changsha,Changsha 410075,China)
出处 《临床合理用药杂志》 2019年第9期3-5,共3页 Chinese Journal of Clinical Rational Drug Use
基金 长沙市科技局项目(kq1706005) 长沙市第三医院后备人才培养基金项目
关键词 帕金森病 痴呆 丁苯酞软胶囊 炎性因子 认知功能 影响 Parkinson disease Dementia Butylphthalide soft capsule Inflammatory factors Cognitive function Influence
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