注射用牛肺表面活性剂联合持续气道正压通气治疗新生儿呼吸窘迫综合征的临床疗效

Clinical effect of calf pulmonary surfactant for injection combined with CPAP for neonatal respiratory distress syndrome

目的探讨注射用牛肺表面活性剂联合持续气道正压通气(CPAP)治疗新生儿呼吸窘迫综合征的临床疗效。方法选取铜仁市人民医院2017年1月—2018年1月收治的呼吸窘迫综合征患儿50例,随机分为对照组和观察组,各25例。对照组患儿采用常规治疗,观察组患儿采用注射用牛肺表面活性剂联合CPAP治疗。比较两组患儿治疗前后血气分析指标〔pH值、动脉血氧分压(PaO2)及动脉血二氧化碳分压(PaCO2)〕、CPAP参数变化情况〔呼气末正压、吸入氧浓度、呼吸频率(RP)、平均动脉压(MAP)、吸气峰压(PIP)〕及临床疗效、并发症情况,并比较两组患儿肺野透明度改善情况。结果治疗前,两组患儿pH值、PaO2、PaCO2及呼气末正压、吸入氧浓度、RP、MAP、PIP比较,差异无统计学意义(P>0.05);治疗后,观察组患儿pH值、PaO2、RP、MAP、PIP高于对照组,PaCO2、呼气末正压、吸入氧浓度低于对照组(P<0.05)。观察组患儿治愈率、肺野透明度改善率高于对照组(P<0.05)。两组患儿均未出现严重并发症。结论注射用牛肺表面活性剂联合CPAP治疗新生儿呼吸窘迫综合征的临床疗效确切,可明显改善患儿动脉血气分析指标,提高其肺泡通换气功能,促进患儿康复,且安全性高。

Objective To discuss the clinical effect of calf pulmonary surfactant for injection combined with CPAP for neonatal respiratory distress syndrome.Methods A total of 50 cases of neonatal respiratory distress syndrome children were selected from January 2017 to January 2018 in Tongren People’s Hospital,which were randomly divided into control group and observation group,25 cases in each group.The control group was given routine treatment,and the observation group was treated with calf pulmonary surfactant for injection combined with CPAP.The blood gas analysis indexes(pH value,PaO2,PaCO2),CPAP parameters(PEEP,FiO2,RP,MAP,PIP)before and after treatment,clinical effect and the incidence of complications were compared between the two groups,and the improvement of lung field transparency were compared between the two groups.Results Before treatment,no significant differences of pH value,PaO2,PaCO2,PEEP,FiO2,RP,MAP or PIP was found between the two groups(P>0.05);after treatment,the observation group of pH value,PaO2,RP,MAP,PIP were higher than control group,PaCO2,PEEP,FiO2 were lower than control group(P<0.05).The observation group of cure rate,improvement rate of lung field transparency were higher than control group(P<0.05).No serious complications was happened.Conclusion Calf pulmonary surfactant for injection combined with CPAP have an exact clinical effect for neonatal respiratory distress syndrome,which can obviously improve the blood gas analysis indexes of children,improve alveolar ventilation function,and promote the recovery of children,and with high safety.