盐酸坦洛新缓释胶囊治疗输尿管结石并前列腺增生临床疗效观察

Clinical efficacy of tamsulosin hydrochloride sustained-release capsule in the treatment of ureteral calculi complicated with benign prostatic hyperplasia

目的观察盐酸坦洛新缓释胶囊治疗输尿管结石并前列腺增生的临床疗效。方法选取医院2015年1月-2017年1月收治的输尿管结石并前列腺增生患者70例。根据治疗方法不同分为观察组和对照组各35例,观察组给予盐酸坦洛新缓释胶囊治疗,对照组给予山莨菪碱治疗。对比2组患者排石率、治疗前后前列腺增生症状评分及不良反应发生情况。结果观察组患者的排石率为74.29%(26/35),对照组患者的排石率为65.71%(23/35),2组患者排石率比较差异无统计学意义(χ~2=1.7528,P>0.05)。治疗前2组患者IPSS评分比较差异无统计学意义(P>0.05);治疗后观察组患者IPSS评分低于治疗前,对照组患者IPSS评分高于治疗前及观察组,且出现急性尿潴留2例,差异均有统计学意义(P<0.05)。观察组患者未出现明显不良反应;对照组患者出现不同程度的心悸、腹胀、口干10例,但均可耐受。结论盐酸坦洛新缓释胶囊治疗输尿管结石并前列腺增生效果较好,可有效避免抗胆碱药物不良反应,值得临床推广。

Objective To observe the clinical efficacy of tamsulosin hydrochloride sustained-release capsule in the treatment of ureteral calculi complicated with benign prostatic hyperplasia.Methods Seventy patients with ureteral calculi and benign prostatic hyperplasia admitted to the hospital from January 2015 to January 2017 were selected.According to the different treatment methods,they was divided into observation group and control group,each of 35 cases.Observation group was treated with tamloxine hydrochloride sustained-release capsule,and control group was treated with anisodamine.The stone discharge rate,the score of benign prostatic hyperplasia and the incidence of adverse reactions before and after treatment were compared.Results The stone removal rate was 74.29%(26/35)in observation group and 65.71%(23/35)in control group,there was no significant difference in the stone discharge rate between two groups(χ~2=1.7528,P>0.05).There was no significant difference in the IPSS scores between two groups before treatment(P>0.05);After treatment,the IPSS score of observation group was lower than that before treatment,the IPSS score of control group was higher than that of pre-treatment and observation groups,and there were 2 cases of acute urinary retention,the difference was statistically significant(P<0.05).Conclusion Tamloxine hydrochloride sustained-release capsule is effective in the treatment of ureteral calculi with benign prostatic hyperplasia,and can effectively avoid the side effects of anticholinergic drugs,which is worthy of clinical promotion.