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雷公藤多苷和糖皮质激素联合低分子肝素治疗特发性膜性肾病的临床效果观察 被引量:4

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摘要 目的观察雷公藤多苷和糖皮质激素联合低分子肝素治疗特发性膜性肾病的临床效果。方法回顾性分析100例特发性膜性肾病患者临床资料。根据治疗方案不同分为观察组和对照组,每组50例。对照组患者予常规治疗,观察组患者予雷公藤多苷和糖皮质激素联合低分子肝素方案治疗。比较2组治疗效果,治疗前后相关指标改善情况及不良反应发生情况。结果观察组完全缓解率为68. 0%,高于对照组的42. 0%(P <0. 01);观察组治疗总有效率为94. 0%,高于对照组的68. 0%(P <0. 01);治疗后,2组相关指标均较治疗前改善,且观察组尿蛋白、纤维蛋白原、空腹血清胆固醇和D-二聚体水平改善程度好于对照组(P <0. 05)。2组不良反应总发生率比较差异无统计学意义(P> 0. 05)。结论雷公藤多苷和糖皮质激素联合低分子肝素治疗特发性膜性肾病的临床效果肯定,且不会增加药物不良反应发生风险,值得临床推广应用。
作者 谢潜红
出处 《临床合理用药杂志》 2019年第17期55-56,共2页 Chinese Journal of Clinical Rational Drug Use
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  • 1李涛,涂明利,张庆红,费沛,张建鄂.肾病综合征地塞米松冲击治疗新用法探讨[J].临床内科杂志,2002,19(S1):85-87. 被引量:2
  • 2Ponticelli C, Passerini P. Membranous glomerulonephritis//Massry SG, Glassock RJ, et al. Massry & Glassock's Textbook of Nephrology. 4th ed. Philadelphia: Lippineott Williams Wilkins,2001,707 - 713.
  • 3Donadio JV Jr, Torres VE, Velosa JA, et al. Idiopathic membranous nephropathy: the natural history of untreated patients. Kidney Int, t988,33 (3) :708 - 715.
  • 4Li LS, Liu ZH. Epidemiologic data of renal diseases from a single unit in China:Analysis based on 13,519 renal biopsies. Kidney Int,2004, 66 (3) :920 - 923.
  • 5Ponticelli C, Zucchelli P, Imbasciati E, et al. Controlled trial of methylprednisolone and chlorambucil in idiopathic membranousnephropathy. N Engl J Med, 1984,310 ( 15 ) :945 - 950.
  • 6Ponticelli C, Zucchelli P, Passerini P, et al. A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephrophthy. N Engl J Med,1989,320(10) :8 - 13.
  • 7Ponticelli C, Zucchelli P, Passerini P, et al. Methylprednisolone plus chlorambucil as compared with methylprednisolone alone for the treatment of idiopathic membranous nephropathy. N Engl J Med, 1992,327 (9) :599 - 603.
  • 8Pontieelli C,Zuechelli P, Passerini P, et al. A I 0-year follow-up of a randomized study with methylpredisolone and chlorambucil in membranous nephropathy. Kidney Ittt, 1995,48 (5) :1600 - 1604.
  • 9Ponticelli C, Altieri P, Scolari F, et al. A randomized study comparing methylprednisolone plus chorambucil versus methylprednisolone plus cyclophosphamide in idiopathic methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol, 1998,9 ( 3 ) :444 - 450.
  • 10Eriguchi M, Oka H, Mizobuchi T, et al. Long-term outcomes of idiopathic membranous nephropathy in Japanese patients treated with low-dose cyelophosphamide and prednisolone. Nephrol Dial Transplant ,2009,24(10) :3082 - 3088.

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