氯胺酮复合丙泊酚联合瑞芬太尼在小儿麻醉中的应用效果

Application of ketamine combined with propofol and remifentanil in pediatric anesthesia

目的探讨氯胺酮复合丙泊酚联合瑞芬太尼在小儿麻醉中的应用效果。方法选取2017年于福建医科大学附属宁德市医院接受手术治疗的患儿120例,根据病床奇偶数分为对照组与研究组,各60例。对照组患儿在麻醉诱导基础上静脉注射氯胺酮进行麻醉,研究组在对照组基础上静脉注射瑞芬太尼进行麻醉。比较两组患儿麻醉诱导时间、苏醒时间、定向力恢复时同、离院时间,给药后20、40 min视觉模拟评分法(VAS)评分,观察两组患儿不良反应发生情况。结果研究组患儿麻醉诱导时间、苏醒时间、定向力恢复时间、离院时间短于对照组(P<0.05)。研究组患儿给药后20、40 min VAS评分低于对照组,不良反应发生率低于对照组(P<0.05)。结论氯胺酮复合丙泊酚联合瑞芬太尼在小儿麻醉中的应用效果较好,可减轻疼痛程度,且安全性较高。

Objective To investigate the application of ketamine combined with propofol and remifentanil in pediatric anesthesia.Methods A total of 120 cases of children who underwent surgical treatment were selected from 2017 in Ningde Hospital Affiliated to Fujian Medical University,which were divided into control group and research group according to the parity of beds,with 60 cases in each group.The control group was anesthetized by intravenous ketamine based on anesthesia induction,while the research group was anesthetized by intravenous remifentanil based on the control group.The induction time of anesthesia,recovery time,orientation recovery time and discharge time were compared between the two groups.VAS scores were evaluated 20 and 40 minutes after administration.The adverse reactions of the two groups were observed.Results The induction time of anesthesia,recovery time,orientation recovery time and discharge time in the research group were shorter than the control group(P<0.05).The research group of the VAS score was lower than the control group at 20 and 40 minutes after administration,and the incidence rate of adverse reactions was lower than the control group(P<0.05).Conclusion Ketamine combined with propofol and remifentanil has a better effect in pediatric anesthesia,it can reduce the degree of pain,and with high safety.