阿咖酚散与腔隙性脑梗死的关系分析

Analysis of the relationship between akafen powder and lacunar infarction

目的分析阿咖酚散与腔隙性脑梗死(LI)的关系。方法回顾性收集医院100例LI患者和98例长期服用阿咖酚散慢性头痛患者的临床资料,其中有阿咖酚散长期服用史48例(48.00%)为A组,其余52例患者为B组;另外长期服用阿咖酚散的慢性头痛患者98例为C组。比较随访期内A组、B组LI复发情况,分析长期服用阿咖酚散对LI复发的影响;并统计随访期内C组LI发生情况。结果 A组、B组、C组高血压、糖尿病、动脉粥样硬化、高脂血症等脑梗死危险因素发生情况及脑梗死家族史比较差异无统计学意义(P>0.05)。与C组比较,A组年龄明显大,头痛病程明显较长,头痛发生频率、疼痛强度明显高,差异均有统计学意义(P<0.05)。随访2年,A组LI复发率为37.50%显著高于B组的19.23%,差异有统计学意义(P<0.05);随访期内C组LI发生率达22.45%。结论长期服用阿咖酚散慢性头痛与LI的关系密切,头痛病程长、程度严重均可增加LI发病风险,并可影响LI的预后。

Objective To analyze the relationship between akafen powder and lacunar infarction.Methods The clinical data of 100 patients with LI and 98 patients with chronic headache who took akafen powder for a long time were analyzed retrospectively,among them,48 patients(48.00%)with history of long-term use of akafen powder were included in group A,and the other 52 patients were included ingroup B;98 patients with chronic headache and took akafen powder for a long time were included in group C.All patients were followed up for at least 2 years,the recurrence of LI in group A and group B was compared during the follow-up period,the effect of long-term administration of acaphenol powder on the recurrence of LI was analyzed;The incidence of LI in group C was counted during the follow-up period.Results There were no significant differences of the incidence of cerebral infarction dangerous diseases such as hypertension,diabetes mellitus,atherosclerosis and hyperlipidemia and family history of cerebral infarction among the three groups(P>0.05).Compared with patients in group C,patients in group A were significantly older,the duration of headache was significantly longer,the frequency of headache and the intensity of pain were significantly higher(P<0.05).All patients were followed up for at least 2 years,the recurrence rate of LI in group A(37.50%)was significantly higher than that in group B(19.23%)during follow-up(P<0.05);In group C,the incidence of LI was 22.45%during follow-up period.Conclusion Long-term use of akafen powder is closely related to Li in patients with chronic headache.The long duration and severe headache can increase the risk of LI,and can affect the prognosis of LI.