期刊文献+

注射用甲磺酸加贝酯治疗急性重症胰腺炎的临床疗效及其安全性 被引量:1

Clinical efficacy and safety of gabexate mesylate for injection in the treatment of acute severe pancreatitis
下载PDF
导出
摘要 目的探讨注射用甲磺酸加贝酯治疗急性重症胰腺炎的临床疗效及其安全性。方法选取内江市市中区人民医院2017年1月—2018年6月收治的急性重症胰腺炎患者160例,随机分为对照组和观察组,各80例。对照组患者给予注射用醋酸奥曲肽治疗,观察组患者在对照组基础上给予注射用甲磺酸加贝酯治疗,两组患者均持续治疗14 d。比较两组患者临床疗效,治疗前及治疗后7、14 d腹内压、尿淀粉酶、二胺氧化酶,肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、白介素10(IL-10)、D-乳酸、内毒素、尿甘露醇(L)/乳果糖(M),并观察两组患者不良反应发生情况。结果观察组患者总有效率高于对照组(P<0.05)。治疗前两组患者腹内压、尿淀粉酶、二胺氧化酶,TNF-α、IL-6、IL-10,D-乳酸、内毒素、尿L/M比较,差异无统计学意义(P>0.05);治疗后7、14 d观察组患者腹内压、尿淀粉酶、二胺氧化酶,TNF-α、IL-6,D-乳酸,内毒素、尿L/M低于对照组,IL-10高于对照组(P<0.05)。两组患者治疗期间均无不良反应发生。结论注射用甲磺酸加贝酯治疗急性重症胰腺炎的临床疗效确切,可有效改善临床症状,遏制胰腺炎症状态,且安全性较高。 Objective To investigate the clinical efficacy and safety of gabexate mesylate for injection in the treatment of acute severe pancreatitis.Methods A total of 160 cases of patients with severe acute pancreatitis were selected from January 2017 to June 2018 in Neijiang Central Area People’s Hospital,which were randomly divided into control group and observation group,80 cases in each group.The control group were treated with octreotide acetate for injection based on routine treatment,while the observation group were treated with gabexate mesylate for injection based on the control group.Both groups were treated continuously for 14 days.The clinical effects of the two groups were compared,including intra-abdominal pressure,urinary amylase,diamine oxidase,TNF-α,IL-6,IL-10,D-lactic acid,endotoxin and urinary mannitol(L)/lactulose(M)before and 7 and 14 days after treatment.The occurrence of adverse reactions during treatment was observed in both groups.Results The total effective rate of the observation group was higher than the control group(P<0.05).There was no significant differences in intra-abdominal pressure,urinary amylase,diamine oxidase,TNF-α,IL-6,IL-10,D-lactic acid,endotoxin or urinary L/M between the two groups before treatment(P>0.05);7 and 14 days after treatment,the observation group of the intra-abdominal pressure,urinary amylase,diamine oxidase,TNF-α,IL-6,D-lactic a cid,endotoxin and urinary L/M were lower than the control group;IL-10 was higher than control group(P<0.05).There were no adverse reactions during treatment in both groups.Conclusion Gabexate mesylate for injection is effective in treating acute severe pancreatitis,it can effectively improve clinical symptoms,curb pancreatic inflammation,and with high safety.
作者 郑永洁 ZHENG Yong-jie(Department of Emergency,Neijiang Central Area People's Hospital,Neijiang 641000,China)
出处 《临床合理用药杂志》 2019年第24期25-27,共3页 Chinese Journal of Clinical Rational Drug Use
关键词 胰腺炎 急性 重症 注射用甲磺酸加贝酯 治疗结果 Pancreatitis Acute Severe Gabexate mesilate for injection Treatment outcome
  • 相关文献

参考文献9

二级参考文献65

共引文献91

同被引文献15

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部