布地奈德氧驱雾化吸入治疗小儿哮喘急性发作的疗效及对患儿肺功能的影响

Clinical effect of budesonide oxygen inhalation in the treatment of acute asthma attack in children and its effect on lung function in children

目的观察布地奈德氧驱雾化吸入治疗小儿哮喘急性发作患儿的临床效果以及对肺功能产生的影响。方法选择医院收治的小儿哮喘急性发作患儿66例,随机分为观察组和对照组,每组33例。对照组选择硫酸特布他林雾化器给药吸入治疗,观察组选择布地奈德氧驱雾化吸入治疗,比较2组治疗总有效率,治疗前后2组各项肺功能指标[呼吸气流量峰值(PEF)、第一秒用力呼吸值(FEV1)以及用力肺活量(FVC)]变化情况,以及喘息、咳嗽、呼吸困难、肺部哮鸣音消失时间。结果观察组治疗总有效率为96. 97%,高于对照组的66. 67%(P <0. 01);治疗后,2组PEF、FEV1、FVC数值较治疗前升高,且观察组各指标升高幅度大于对照组(P <0. 05或P <0. 01);观察组喘息、咳嗽、呼吸困难、肺部哮鸣音消失时间均短于对照组(P <0. 01)。结论小儿哮喘急性发作患儿采用布地奈德氧驱雾化吸入治疗,对于患儿哮喘疗效提高,各项肺功能指标改善,缩短相关症状与体征的消失时间的作用明显,最终对于哮喘急性发作患儿康复状态的提升奠定基础。

Objective To observe the clinical effect of budesonide oxygenation inhalation in the treatment of acute asthma attack in children and its effect on lung function in children.Methods Sixty-six children with acute asthma attack in the hospital were selected and randomly divided into observation group and control group,with 33 cases in each group.The control group was treated with inhalation of terbutaline sulfate by nebulizer,and the observation group was treated with budesonide by atomization inhalation.The therapeutic effects of the two groups of patients,the changes of lung function indexes(PEF,FEV1,FVC)in the two groups before and after treatment,and the disappearance time of symptoms and signs such as wheezing,cough,dyspnea,and lung wheezing were compared.Results The total effective rate of the observation group was96.97%,which was higher than that of the control group(66.67%,P<0.01).After treatment,the PEF,FEV1,and FVC values of the two groups were higher than those before treatment,and the increase of each index in the observation group was greater than that of the control group(P<0.05 or P<0.01).In the observation group,the disappearance time of symptoms and signs such as wheezing,cough,dyspnea,and lung wheezing was shorter than that of the control group(P<0.01).Conclusion Inhalation of budesonide by oxygenation in the treatment of acute asthma attacks in children is effective in improving the curative effect,improving various lung function indexes,and shortening the disappearance time of related symptoms and signs.Finally,it lays the foundation for the improvement of the rehabilitation status of children with acute asthma attacks.