红霉素与阿奇霉素治疗小儿肺炎支原体肺炎临床疗效的比较研究

A comparative study of erythromycin and azithromycin in treating mycoplasma pneumonia in children

目的比较红霉素与阿奇霉素治疗小儿肺炎支原体肺炎的临床疗效。方法选取连云港市妇幼保健院2017年7月—2018年7月收治的肺炎支原体肺炎患儿101例,按照抽签结果分为对照组50例与观察组51例。对照组予以红霉素治疗,观察组予以阿奇霉素治疗。比较两组临床疗效、临床症状(咳嗽、发热、肺部啰音)消失时间,并观察两组不良反应发生情况。结果观察组治疗总有效率高于对照组,咳嗽、发热、肺部啰音消失时间短于对照组,不良反应发生率低于对照组(P<0.05)。结论与红霉素比较,阿奇霉素治疗小儿肺炎支原体肺炎的临床疗效更好,可在较短时间改善临床症状,且安全性更高。

Objective To compare the clinical efficacy of erythromycin and azithromycin in treating mycoplasma pneumonia in children.Methods A total of 101 cases of children with mycoplasma pneumoniae pneumonia were selected from July 2017 to July 2018 in Lianyungang Maternal and Child Health Hospital,which were divided into control group(n=50)and observation group(n=51)according to the results of random lottery.The control group was treated with erythromycin and the observation group was treated with azithromycin.The clinical efficacy and the disappearance time of clinical bed symptoms(cough,fever and lung rale)were compared between the two groups,and the occurrence of adverse reactions was observed.Results The observation group of the total effective rate was higher than the control group,the disappearance time of cough,fever and lung rale were shorter than the control group,and the incidence rate of adverse reactions was lower than the control group(P<0.05).Conclusion Compared with erythromycin,azithromycin has better clinical efficacy in treating mycoplasma pneumoniae pneumonia in children,it can improve clinical symptoms in a short time and with high safety.