摘要
As a synergistic anti tumor agent, N solanesyl N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(5) was synthesized starting from vanillin and solanesol. Methylation of vanillin gave veratradehyde(1), which after coupling with ethylenediamine was then catalytically reduced to N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(3), which was coupled with solanesol bromide (4) to give (5). The processes of synthesis of (3) and separation of (5) have been improved with total reaction yield being increased. The structures of the compounds were confirmed by IR, 1 H NMR, MS and elemental analysis.
As a synergistic anti tumor agent, N solanesyl N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(5) was synthesized starting from vanillin and solanesol. Methylation of vanillin gave veratradehyde(1), which after coupling with ethylenediamine was then catalytically reduced to N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(3), which was coupled with solanesol bromide (4) to give (5). The processes of synthesis of (3) and separation of (5) have been improved with total reaction yield being increased. The structures of the compounds were confirmed by IR, 1 H NMR, MS and elemental analysis.
出处
《应用化学》
CAS
CSCD
北大核心
2003年第8期797-799,共3页
Chinese Journal of Applied Chemistry
基金
国家教育部面向 2 1世纪教育振兴行动计划资助项目
中国科学院青年科技资金资助项目
