布地奈德联合沙丁胺醇治疗小儿哮喘急性发作

Budesonide in Combination with Salbutamol in the Treatment of 61 Cases of Childhood Bronchial Asthma During Acute Episodes

目的 :观察布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作的临床疗效。方法 :115例哮喘急性发作患儿随机分为治疗组 61例 ,对照组 5 4例。治疗组每次给予布地奈德 0 .5～ 1.0mg加 0 .5 %沙丁胺醇雾化液 0 .2 5～1.0 0mL ,对照组仅给予 0 .5 %沙丁胺醇雾化液 ,两组均雾化吸入 3 .0 0mL。结果 :治疗组临床控制率 47.5 % ,显效率3 1.1% ,好转率 16.4% ,总有效率 95 .1% ;对照组临床控制率 3 3 .3 % ,显效率 2 9.6% ,好转率 2 4.1% ,总有效率 87.0 %。治疗组明显优于对照组 (P <0 .0 5 )。结论 :布地奈德联合沙丁胺醇雾化吸入治疗哮喘患儿急性发作临床疗效确切 ,起效迅速 。

Objective:To survey the clinical effectiveness of budesonide combined with salbutamol in the treatment of acute episodes of childhood asthma. Methods:115 children with bronchial asthma during acute episodes were randomly divided into two groups: 61 in the treatment group and 54 in control group. Patients of the treatment group were given each an aerosol inhalation of 0.5-1.0 mg of budesonide combined with 0.25～1.00 mL of 0.5% solbutamol salution while patients of the control group were given aerosol inhalation of 0.5% salbutamol solution only. The inhalation lasted 7～10 min. in both groups. Results:The rates of clinical control were 47.5% and 33.3%, rates of excellent effect were 31.1% and 29.6%, rates of improvement were 16.4% and 24.1% and the total effective rates were 95.1% and 87.0% in the treatment group and control group, respectively. The effect of the treatment group was strikingly superior to that of the control group ( P <0.05). Conclusion:Aerosol inhalation of budesonide in combination with salbutamol was shown to have definite effect and quick action in the emergency treatment of childhood bronchial asthma during its acute episodes. The author suggests to spread the clinical application of this therapeutic scheme.