丁咯地尔治疗新生儿缺氧缺血性脑病39例

The Effect of Fonzylane in the Treatment of 39 Cases of Hypoxic Ischemic Encephalopathy in Neonates

目的 :观察丁咯地尔治疗新生儿缺氧缺血性脑病 (HIE)的临床疗效。方法 :中度HIE患儿 81例 ,随机分为治疗组 3 9例 ,对照组 42例。治疗组给予丁咯地尔 10mg·kg 1 ·d 1 ,加入 5 %葡萄糖注射液 2 0～ 3 0mL静脉滴注 ,qd ;对照组给予胞二磷胆碱 0 .12 5g·d 1 ,加入 5 %葡萄糖注射液 2 0～ 3 0mL静脉滴注 ,qd ,均 10d为 1个疗程。结果 :治疗组和对照组有效率分别为 94.9% ,80 .5 % (P <0 .0 5 ) ;治疗组在血清肌酸激酶同工酶 (CK MB)的恢复、新生儿行为神经测定(NBNA)评分和临床症状的恢复等方面均优于对照组 (P <0 .0 1或 0 .0 5 ) ,未发现明显不良反应。结论 :丁咯地尔对中度HIE疗效显著。

Objective:To survey the clinical effectiveness of fonzylane in the treatment of hypoxic ischemic encephalopathy (HIE) in neonates. Methods:81 newborns diagnosed as moderate HIE were divided randomly into two groups. 39 cases of the treatment group were given each a daily dose of 10 mg·kg 1 of fonzylane in 20～30 mL of 5% glucose solution administered by intravenous instillation. 42 newborns of the control group were given each a daily dose of 0.125 g of citicoline in 20～30 mL of 5% glucose solution administerd by intravenous instillation as well. The course of treatment in both groups lasted 10 days. Results:The overall effective rates were 94.9% and 80.5%( P <0.05) in the treatment group and control group, respectively. Recovery of serum Creatine Kinase isoenzymes (CK MB), Neonatal Behavioral Neurological Assessment (NBNA) scoring and abatement of clinical symptoms in patients of the treatment group were far more striking than those of the control group ( P <0.01 or <0.05). No major adverse reactions were encountered. Conclusion:Fonzylane was shown to be fairly effective in the treatment of moderate HIE of neonates.