桃花止泻冲剂的药效学研究

Pharmacodynamics Study on "Tao Hua Zhi Xie Granule

采用炭末推进法和药物性腹泻模型 ,观察了桃花止泻冲剂对小鼠小肠推进运动、药物性腹泻的影响 ,并初步观察桃花止泻冲剂的抗炎作用。结果表明 ,桃花止泻冲剂能明显抑制新斯的明引起的小鼠小肠推进亢进作用 ,减少番泻叶引起的小鼠腹泻发生率和次数 ,并具有剂量依赖性。桃花止泻冲剂 11 70和 17 5 5g/kg剂量组能明显抑制乙酸引起小鼠腹腔毛细血管通透性的增高。

The anthraco propulsion and the drug induced mice diarrhea models were used to observe the intestine propulsion and the anti diarrhea effect of 'Tao Hua Zhi Xie Granule'(THZXG),and the anti inflammation effect of THZXG was studied.The results showed that THZXG could obviously reduce the incidence and frequency of the mice diarrhea induced by Folium Sennae and castor oil,and propelling movement of mice small intestine after hypodermic injection of neostigmine.The actions were acted in a dose dependent manner. 11.70 and 17.55 mg/kg THZXG(ig) could also inhibit the increased permeability of intraperitoneal capillary induced by acetic acid in mice.