阿昔洛韦纳米乳剂在大鼠体内的药代动力学

Study on the pharmacokinetics of acyclovir nanemulsions in rats

目的制备阿昔洛韦纳米乳剂,探讨其在大鼠体内的药代动力学。方法对大鼠尾静脉注射后不同时间点眼眶采血,用HPLC法测定阿昔洛韦血药浓度,3p87软件拟合药动学参数。结果阿昔洛韦在大鼠体内呈二室模型,t1/2α为20.74min,t1/2β为380.87min,清除率(CL)为0.0018。结论将阿昔洛韦制成纳米乳剂可提高其相对生物利用度,从而增强其抗病毒作用。

Objective To study the pharmacokinetics of acyclovir nanemulsions in rats. Methodes The blood samples were collected at different times after administration in rats.The plasma concentrations of acyclovir were determined by HPLC.The pharmacokinetic parameters were calculated by a pharmaceutic soft ware named 3p87. Results Acyclovir was disposed as a two-compartment model in rats. Conclusions The anti-virus function of acyclovir are improved by use of nanoemulsion.