蛇床子素和欧前胡素大鼠小肠吸收特性

Absorptive feature of imperatorin and osthol in the rat'intestines

目的从其吸收部位、药物浓度两个方面对蛇床子的主要成分欧前胡素、蛇床子素的吸收特性进行研究。方法采用在体大鼠肠段回流实验。结果欧前胡素、蛇床子素在小肠上部吸收最佳;在小肠中部及下部吸收无明显差异,但较小肠上部相比稍差。欧前胡素、蛇床子素在肠道中的吸收量与其浓度呈线性关系,随着药物浓度的增大吸收量增加,其吸收百分率基本不变。结论欧前胡素、蛇床子素在肠道中吸收良好,吸收机制为被动转运。

Objective To study the feature of imperatorin and osthol in the rat'intestines. Methods With the ligation test in segment of the intestines of a rat in vivo,the effect of the segments of intestines and drug concentration of absorption of imperatorin and osthol were studied. Results The absorption of imperatorin and osthol was as well as that in liem. The absorption was liner at different concentrations.No saturation phenomenon occurred. Conclusion The mechanism of the gastrointestinal absorption of imperatorin and osthol is passive diffusion.