摘要
目的制备辅酶Q10脂质体,并考察其稳定性。方法采用乙醇注入法制备辅酶Q10脂质体,并考察其稳定性。结果制备的辅酶Q10脂质体在25℃和40℃下较稳定,在60℃下较不稳定,在光照条件下很不稳定。结论辅酶Q10脂质体制备工艺简单,包封率高,粒径小而均一,稳定性较好。
Objective To prepare Coenzyme Q10(CoQ10)liposome,and study its stability.Method The CoQ10liposome was prepared by ethanol injection method,and stability of CoQ10liposome was reviewed.Results The CoQ10liposome was stable at 25 ℃ and 40 ℃,and unstable at 60℃.Conclusion The CoQ10liposome prepared by ethanol injection is stable,with a high encapsulation efficiency,small particle sizes and narrow distribution.
出处
《中国药剂学杂志（网络版）》
2006年第2期37-40,共4页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
脂质体
乙醇注入
辅酶Q10
稳定性
pharmaceutics
liposomes
ethanol injection
coenzyme Q10
stability
