固体脂质纳米粒制备方法的研究进展

Developments on preparing solid Lipid nanoparticles

目的讨论固体脂质纳米粒的制备方法的研究进展。方法通过分析、整理和归纳近几年的国内外文献,介绍固体脂质纳米粒的常用的制备方法、载体材料、存在的不足及改进方法。结果与结论固体脂质纳米粒制备方法多种多样并日趋成熟,所存在的问题已逐渐被解决,该种制剂极具发展前景。

Objective To review methods for preparing solid lipid nanoparticles(SLNs). Methods According to the recent literatures, the preparation methods were summarized. Furthermore, carriers,existing problems of SLNs and their solutions were included. Result and Conclusion There were various methods for SLNs preparation, among which the high pressure homogenization and microemulsion were used most widely. Several approaches were developed to solve the inherent problems of SLNs which made it a promising dosage form in the pharmaceutical field.