阿昔洛韦棕榈酸酯亚微乳剂的制备及理化性质考察

Preparation and properties of acyclovir palmitate submicron emulsion

目的制备阿昔洛韦棕榈酸酯(acyclovir palmitate,ACVP)亚微乳并对其理化性质进行考察。方法采用高压匀质法制备O/W型ACVP亚微乳,并测定其粒径及分布、Zeta电位、pH值和含量,对其稳定性进行评价。结果在所得处方工艺条件下,所制备的ACVP亚微乳平均粒径为(206±26)nm,Zeta电位为–35.8 mV,pH值为7.38,含量符合要求。结论制备的ACVP亚微乳稳定性良好。

Objective To prepare the acyclovir palmitate( ACVP) submicron emulsion.Methods The ACVP O/W submicron emulsion was prepared by high-pressure homogenization method.In order to evaluate the stability of the ACVP submicron emulsion,the physical properties such as emulsion droplet size distribution,Zeta potential,pH and content were determined.Results The mean droplet size was(206±26) nm,Zeta potential was –35.8 mV,pH was 7.78,and the content was eligible.Conclusion The ACVP submicron emulsion was stable with good results.