依托度酸固体分散体的制备

Preparation of etodolac solid dispersion systems

目的制备依托度酸固体分散体,以提高依托度酸的溶出度。方法分别以PEG4000、PEG6000为单一载体以及PEG4000-PEG6000为联合载体,用溶剂-熔融法制备依托度酸固体分散体,考察其体外溶出速率,并通过差示扫描量热法(DSC)进行鉴定。结果与原料依托度酸制备的制剂相比,依托度酸固体分散体能明显加快药物的溶出;载体材料一定时,依托度酸溶出速率随药物-载体比例的增加而减小。结论依托度酸PEG固体分散体能提高药物的体外溶出度。

Objective To prepare the etodolac solid dispersion for enhancing its dissolution in vitro.Methods Solvent-melting method was used to prepare solid dispersion with PEG4000, PEG6000 or PEG4000-PEG6000 as the carrier. Dissolution study and diferential scan calorimetry(DSC) study were performed to investigate the change of characteristics and the improvement of drug dissolution. Results The solid dispersions prepared could improve the dissolution of the drug apparently compared with the original crystals of etodolac. With the increasing of the ratio of drug-carrier, the dissolution of drug was degraded. Conclusion The etodolac-PEG solid dispersion could enhance the drug dissolution in vitro.