高尿酸血症与颈动脉粥样硬化的关系

Relationship between hyperuricemia and carotid atherosclerosis

目的研究高尿酸血症与颈动脉粥样硬化的关系,为临床治疗与预防提供证据。方法随机选择在本院2012年1月~2014年1月体检发现有颈动脉粥样硬化的患者110例为硬化组,所有患者均经血管超声检查证实。硬化组中男性105例,女性5例,平均年龄(61.3±11.8)岁,其中高尿酸血症92例,定义为合并组。另外在本院选择110例健康志愿组,男性104例,女性6例,平均年龄(61.9±12.3)岁,作为健康组。采用Pearson单因素及多元Logistic回归分析两组患者的高血压、高尿酸血症等因素与颈动脉粥样硬化的关系。对比合并组与健康组患者血尿酸(SUA)、C反应蛋白(CRP)等结果。结果硬化组患者中存在高尿酸血症共有92例,明显高于健康组31例。经Pearson单因素分析得出与颈动脉粥样硬化相关的独立危险因素有糖尿病、高血脂、高血压、高尿酸血症等。合并组患者中的SUA、CRP等均明显高于健康组患者,差异具有统计学意义,P<0.05。结论高尿酸血症是引起颈动脉粥样硬化的独立危险因素,高尿酸血症引起粥样硬化的因素包括体内的血管损伤、炎症、尿酸结晶等,有助于针对性治疗与预防颈动脉粥样硬化。

Objective To study the relationship between hyperuricemia and carotid atherosclerosis, and provide the evidence for treating and preventing hyperuricemia. Methods The patients with carotid atherosclerosis confirmed by vessel ultrasound examination were chosen as atherosclerosis group(n=110, male 105, female 5 and average age=61.3±11.8) from Jan. 2012 to Jan 2014. In atherosclerosis group, there were 92 patients diagnosed with hyperuricemia set into combined group. The healthy volunteers were chosen as health group(n=110, male 104, female 6 and average age=61.9±12.3). The relationship among hypertension, hyperuricemia and carotid atherosclerosis were analyzed by using Pearson single factor analysis and multiple Logistic regression analysis. The changes of serum uric acid(SUA) and C-reactive protein(CRP) were compared between combined group and healthy group. Resutls The cases of hyperuricemia(n=92) were significantly more in atherosclerosis group than those in health group(n=31). Pearson single factor analysis showed that diabetes, hyperlipidemia, hypertension and hyperuricemia were risk factors of carotid atherosclerosis. The levels of SUA and CRP were significantly higher in combined group than those in health group(P<0.05). Conclusion Hyperuricemia is an independent risk factor inducing carotid atherosclerosis. Because the factors of hyperuricemia inducing atherosclerosis include vessel lesions, inflammation and uric acid crystal, definitive therapy is necessary for treating and preventing carotid atherosclerosis.