亚叶酸钙加氟尿嘧啶联合奥沙利铂治疗晚期胃癌26例

Calcium folinate,5-FU and oxaliplatin combined therapy in treatment of advanced gastric cancer

目的 :探讨亚叶酸钙加氟尿嘧啶 (5 Fu)持续 72h滴注联合奥沙利铂治疗晚期 /转移性胃癌的临床疗效和毒副作用。方法 :共入选 2 6例。治疗方案为 :在每周期的d1,静脉滴注奥沙利铂 130mg·m-2 ;d1～d3静脉滴注亚叶酸钙 2 0 0mg·m-2 ·d-1;在d1静脉滴注亚叶酸钙结束后 ,静脉注射 5 Fu 0 .75 g ,然后静脉滴注 5 Fu 3.0g·m-2 ,持续 72h(d1～d3)。 4周为 1个周期 ,每例患者至少应用 2个周期。结果 :2 6例晚期胃癌患者获CR 2例 ,PR9例 ,有效率 4 2 .3%。毒副作用主要为骨髓抑制、口腔黏膜炎、腹泻 ,无严重神经损害。结论 :此方法治疗晚期 /转移性胃癌疗效好 ,安全性高。

Objective:To study the efficacy and toxicity of calcium folinate,5 FU and oxaliplatin combined therapy in treatment of advanced gastric cancer.Methods:26 patients were enrolled into the study.The regimen used were:patients were given on each Monday 130mg·m -2 oxaliplatin infusion,on each Monday～Wednesday 200mg·m -2 ·d -1 calcium folinate infusion;after calcium folinate infusion on each Monday,0.75mg 5 FU iv injection were given followed by 3.0g·m -2 5 FU infusion lasted for 72h.1 course of treatment consisted of 4 weeks,each patient at least received 2 courses of treatment.Results:2 patients were CR (complete response),9 patients were PR (partial response) with an overall response rate (CR+PR) of 42.3%.The main toxicity of the regimen was arrest of bone marrow,oral mucositis,diarrhea but no serious nerve damage.Conclusions:The combined therapy for treatment of advanced gastric cancer is safe and effective.