盐酸博安霉素介入治疗肝癌103例

Boanmycin hydrochloride(BAM) in interventional treatment of 103 patients with liver cancer

目的 :对盐酸博安霉素 (BAM )介入治疗原发性肝癌的临床疗效和毒性进行评价。方法 :入选 10 3例 ,单药组 6 5例 ,单用BAM ,肝动脉介入治疗 ,5 0mg ,共 2～ 3次 ;联合用药组 38例 ,每次除用BAM外加用 5 氟尿嘧啶(10 0 0mg)及丝裂霉素 (10～ 2 0mg) ,共 2～ 3次。结果 :单药组有效率 30 .8% ,联合用药组有效率 4 2 .1%。BAM的主要不良反应有发热、寒战、恶心、呕吐。未见骨髓抑制及心、肝、肾功能损害 ,无明显肺毒性反应。结论 :BAM是原发性肝癌介入治疗的有效药物。

Objective:To study the clinical efficacy and toxicity of BAM in interventional treatment of liver cancer.Methods:103 patients were enrolled in the study.38 of them were allocated to receive 50 mg BAM for 2～3 times,and the balance were treated with combined therapy of BAM,5 fluorouacil (1 000 mg) and mitomycin (10～20 mg) for 2～3 times.Results:The total response rate was 30.8% for BAM arm and 42.1% for the combined therapeutic arm.Fever,chill,and GI reactions are the main side effects.Conclusion:BAM is an effective agent in interventional treatment of liver cancer.