多药耐药基因与P53在胃癌组织中表达关系及意义

Relationship and Significance Between MDR-1 and P53 Protein in Carcinoma of Stomach

目的 :检测多药耐药基因 (MDR - 1 )及P5 3在胃癌组织中的表达关系及其临床意义。方法 :应用免疫组化法研究 5 0例胃癌MDR - 1、P5 3蛋白表达。结果 :5 0例胃癌中MDR - 1、P5 3表达随分化程度降低 ,阳性表达率增高 ,分别为 5 7.42 %和 36.5 % ,二者呈正相关。结论 :应用MDR - 1、P5

Purpose:To investigate the relationship between multidrug-resistance gene and P53 protein in carcinoma of stomach.Methods:Microwave immunohistochemical staining was used to detect MDR-1 and P53 in 50 cases of carcinoma of stomach.Results:The positive rate of MDR-1 and P53 was 57.42% and 36.5% respectively in 50 case carcinoma.The expression of P53 was positively correlated with MDR-1 in vavious differentiated carcinoma of stomach.Conclsion MDR-1 and P53 can be an important in prediction of the prognosis carcinoma patients