鼻腔及鼻咽部NK/T细胞淋巴瘤的临床病理分析

Clinical-pathological analysis of NK/T-cell lymphoma on the nasal cavity and nasopharynx

目的 观察鼻咽和鼻腔部位NK/T淋巴瘤的临床病理学特点和免疫组化表型,为诊断和鉴别诊断提供资料。方法 组织病理学观察结合免疫组织化学染色(S-P法)。结果 NK/T淋巴瘤组织结构特点为多形性淋巴细胞增生,大片的凝固性坏死和血管浸润,免疫组化表达CD3、CD45和CD56阳性。结论 NK/T淋巴瘤是与EB病毒感染有关的原发性肿瘤,结合组织学特点和免疫组化表型可以做出正确诊断。

Objective To observe the clinical-pathological features and immunophenotypes of NK/T-cell lymphoma.Methods Histopathologic analysis and immunohistochemical staining(S-P method ) were used. Results Proliferation of pleomorphic lymphocyte, coagulation necrosis of massive tissue and vaso-infiltration were showed in the NK/T lymphoma; tumor cells were positive for CD3、CD45 and CD56. Conclusion NK/T-cell lymphoma was a primary tumor related with EB virus infection, and can be diagnosed according to the histological features and immunophenotypes.