局部晚期鼻咽癌同时放化疗的疗效观察

Efficacy observation for treatment of local later period nasopharyngeal carcinoma with radiotherapy and chemotherapy

目的 提高局部晚期鼻咽癌的局部控制率及总生存率。方法 80例局部晚期鼻咽癌患者前瞻性随机分为放疗合并化疗组(放化组、R+C)和单纯放疗组(单放组、R),放疗方法相同,放化组放疗同时给予顺铂(DDP)和氟尿嘧啶(5-Fu)。结果 随访3年,放化组较单放组残存率及局部复发率明显下降,差异有显著性(P<0.05),远处转移率差异无显著性(P>0.05)。放化组和单放组1,3年生存率分别为95.5%、74.8%和90.0%、59.5%,差异无显著性(P>0.05)。总生存率差异无显著性(P>0.05)放化组毒性较单放组大,后遗症差异无显著性(P>0.05)。结论 放疗合并使用DDP和5-Fu可减少残存率,提高局部控制率。

Objective To improve local control rate and total survival rate of local later period nasopha-ryngeal carcinoma. Methods Eighty patients with local later period nasopharyngeal carcinoma were prespectively divided into two groups randomly: radiotherapy combined chemotherapy group(radiochemotherapy group,group R + C) and radiotherapy alone group(group R) .The radiotherapy regimen was same in the two groups.DDP and 5-Fu were given in group R + C simultaneously. Results All patients were followed up for 3 years. The remainting rate and recuring rate of group R + C was lower than group R. The difference of the two groups was significant( P < 0.05) .The distance metastasis rate and total survival rate had no significant difference( P > 0.05) .The 1-,3-year survival rates of group R+ C and group R were 95.5% ,74.8% ,and 90.0% ,59.5% respectively.There was no significant difference between two groups( P > 0.05) .The side-effects of group R+ C were more serious than group R.There was no significant difference in the sequelae between the two groups. Conclusion The remainting rate could be reduced and the local control rate could be improved by giving DDP and 5-Fu during radiotherapy.