更年期女性心律失常患者血浆心钠素水平的测定

Level of plasma atrial natriuretic peptide in climacteric women

目的通过观察更年期心律失常女性血浆中心钠素(ANP,中文摘要中无须给出英文全名,这不是中文摘要的任务)水平的改变,探讨心律失常的发生与心钠素的关系。方法58例更年期女性分为心律失常组31例和正常对照27例,治疗前及治疗8周后分别用放免法测定血浆心钠素浓度,同时测定心率。结果正常对照组27例血浆ANP基础水平为(15±8)ng/L,心律失常组31例患者为(30±12)ng/L,二者比较具有显著差异(P<0.01),心律失常组抗心律失常治疗有效23例,治疗血浆ANP水平为(17±10)ng/L,与治疗前相比明显降低(P<0.05),血浆ANP水平与心率呈正相关性(r=0.76,P<0.05)。结论更年期女性心律失常患者血浆中ANP水平明显高于正常人群。

Aim To observe the changes of the level of plasma atrial natriuretic pe ptide (ANP) in climacteric women and investigate the relationship between the oc currence of arrhythmia and ANP. Methods By using the radio-immunoassay, the con centration of plasma ANP was measured 31 43-54-year-old climacteric women wit h arrhythmia and treated with anti-arrhythmics,(AG group) before and 8 weeks af ter treatment. The concentration of ANP was measured simultaneously among 27 41 -52-year-old climacteric women without arrhythmia (NG group) used as controls .Results The baseline plasma level of ANP before treatment was (15±8)ng/L in th e NG group and (30±12)ng/L in the AG group respectively (P< 0.01). Twenty-thre e cases were cured after treatment, of which the plasma ANP level was (17±10)ng /L, significantly lower than that before treatment(P< 0.05). The plasma ANP co ncentration of ANP showed a positive correlation with the heart rate (r=0.76, P< 0.05). Conclusion The baseline level of plasma ANP in climacteric women is sign ificantly higher than that in normal cases.