老年感染患者的肠球菌分布及耐药性分析

Distribution of Enterococci in Old People Infection and Drug-fast Analysis

目的 了解肠球菌引起老年患者感染的临床分布及其对常用抗菌药物的耐药性。方法 对 2 0 0 0年 4月至 2 0 0 3年 5月从老年病区临床标本分离出的 2 81株肠球菌进行对常用抗菌药物的耐药性及临床感染分布作回顾性分析。结果 2 81株肠球菌中粪肠球菌占 42 .0 %,屎肠球菌占 5 1.6 %,其它肠球菌占 6 .4%。肠球菌在各类标本中的分离率以尿液、痰液、伤口分泌物最高 ,分别占 71.5 %、17.4%、2 .5 %。药敏结果显示屎肠球菌的耐药性高于粪肠球菌。粪肠球菌对氨苄西林、青霉素、呋喃妥因、万古霉素较敏感 ,对其他抗菌药物高度耐药。结论 粪肠球菌和屎肠球菌是引起医院内感染的常见病原菌 ,引起感染部位以泌尿系统多见。肠球菌属存在严重的耐药性 ,目前万古霉素对肠球菌仍具较高的抗菌活性。

Objective in order to understand clinical distribution of enterococci in old people infection and its tolerance to common antibiotics. Methods 281 strains of enterococci isolated from clinical specimens during the period from April 2000 to May 2003 were tested drug-fast to common antibiotics and retrospective analysis of clinical infection distribution were made. Results Among 281 strains of entercocci, 42.0% were Streptococcus faecalis;51.6% were Streptococcus faecium and 6.4% were other enterococci. Urine, sputum and wound secretion specimen had high enterococci isolation rate in the various specimens. The rates were 71.5%, 17.4% and 2.5% respectively. The results of drug-fast showed that tolerance of Streptococcus faecium was higher than that of Streptococcus faecalis. Streptococcus faecalis was sensitive to ampicillin?penicilin G?nitrofurnantoin?vancomycin and tolerance to other antibiotics.Conclusions Streptococcus faecalis and Streptococcus faecium was common pathogenic bacteria in the hospital infection. Urinary system was the common site of the infection. Enterococci had serious tolerance of to many antibiotics, but still had at present higher sensitivity to vancomycin.