严重急性呼吸综合征及与老年多器官功能衰竭的关系

Severe acute respiratory syndrome and multiple organ failure in the elderly

SARS相关冠状病毒引起严重急性呼吸综合征(SARS)。该病毒在患者痰液中含量最高,在咽喉部和血浆中分布较少,在患者粪便中可长时间存活。微尘和飞沫是主要传播途径。合并多种基础疾病的老年SARS患者易于发生老年多器官功能衰竭(MOFE)可能是其高病死率的主要原因。老年SARS患者启动MOFE的主要机制可能为组织细胞缺氧、血液中内毒素水平升高和全身炎症反应水平、老年人器官储备功能降低。

Severe acute respiratory syndrome (SARS) is caused by SARS- related corona virus. The viral RNA concentration is high in sputum, while low in serum and throat swabs of the patients. Another feature of the virus is its long-term presence in patients' stool. The aged SARS patients with many concomitant diseases tend to develop multiple organ failure in the elderly (MOFE), which may account for the high mortality in the aged patients with SARS. The occurrence of MOFE in the aged SARS patients is thought to be related to several factors including the hypoxia of the tissues or cells, the high level of endotoxin in blood, and the impairment of organ function and systemic inflammatory reaction in the aged.