SHR大鼠病理特性测定研究

Series Study on Pathological Characteristics in SHR

作者对SHR大鼠5个世代的血压、心率、体重、心、脑、肾等脏器病变指标进行了测定,结果表明,SHR已形成能够稳定遗传的高血压特性。成年大鼠血压值(收缩压)平均为189±6 mmHg,已接近日本原种水平(193 mmHg);第六周时已形成高血压,此后血压呈逐周上升趋势,雄性在25周达到最高值(200±9 mmHg),雌性17周达到最高值(178±7 mmHg)。各周测得的血压值均显著高于其背景品系WKY(京都Wistar大鼠);各年龄段体重均低于WKY,初生重为WKY的86％,100日龄重仅为WKY的67％;脑和肾脏器系数SHR显著高于WKY;脑垂体、心脏无论是相对重还是绝对重SHR均显著高于WKY。SHR在疾病发展阶段也形成典型的高血压心血管病变。SHR大鼠与人类原发性高血压最常见的病变一样,具有心脏肥大症状,并观察到心、脑、肾合并症。

The blood pressure(BP), heart rate, body weight and organ weight related to hypertension were monitored and detected in SHR through five generations,the results showed that the SHR had formed hypertensive characters,the average BP in adult SHR was 189±6 mmHg nearly equal to the original SHR (193 mmHg). From 6th week the hypertensive character was appeared in SHR and the BP increased gradually thereafter , reached highest level on 25th week in male (200±9mmHg) and 17th week in female (178±7mmHg). The BP levels of SHR in different ages were significantly higher than that of the background strain (WKY ), whereas the body weight (BW) were lower than WKY, about 86% of WKY on birth and 67% at the age of 100 days . The organ coefficient of the brain and kidney were higher than that of WKY. Both the weight and organ coefficient of the heart and hypophysis were significantly higher than those of WKY . In period of disease development, SHR also appeared typical pathological changes in cardiovascular system. These pathological changes could cause heart hypertrophy and combining symptoms in heart,brain and kidney.