小剂量米索前列醇用于足月妊娠引产效果观察

A study on misoprostol for inducing labor in term pregnancy

目的 :探讨小剂量米索前列醇用于足月妊娠引产的有效性和安全性。方法 :选择 110例有引产指征的足月孕妇 ,随机分成两组 ,米索组 ( 5 8例 )和对照组 ( 5 2例 ) ,分别用米索前列醇 2 5 μg阴道后穹窿放置及用催产素引产。 结果 :米索组引产的总有效率 ( 82 75 %)高于催产素组 ( 71 15 %) ,P <0 0 5 ;米索组从开始用药至临产的平均时间较催产素组明显缩短 ,P<0 0 5 ,低宫颈评分引产成功率米索组 ( 81 81%)显著高于催产素组 ( 4 2 3 1%) ,P <0 0 5。剖宫产率、产后出血及新生儿情况比较无显著差异 (P >0 0 5 )。结论 :小剂量米索前列醇用于足月妊娠引产是一种安全、有效、方便的方法 。

Objective To study the efficacy and safety of small dosage misoprostol for labor induction in term pregnancy.Methods One hundred ten women in term pregnancy with indications of labor induction were randomly divided into group A and group B .Group A was placed 25 μg misoprostol in the posterior vaginal and group B received intravenous oxytocin for control.Results The success rate of labor induction was 82.75% in group A and 71.15% in group B (P< 0.05 ).The average interval from start of labor induction to onset of labor in group A was significantly shorter than that in group B (P<0.05).The success rate of labor induction of lower Bishop Scores in group A (81.81%) was higer than that in group B (42.31%)(P<0.05).No singnificant difference was found among labor patterns,outcome of newborn and postpartum hemorrhage(P>0.05).Conclusion Small dosage of misoprostol is a safe,effective and simple method for labor induction in term pregnancy. [