342例羊水细胞染色体核型结果分析

A karyotyping study on the chromosomes of ammiotic cells from 342 women

目的 :探索羊水细胞染色体核型分析的方法 ,减少染色体病患儿出生。方法 :对 3 42例具有产前诊断指征高风险孕妇抽取孕中期羊水细胞培养 ,制备中期细胞染色体 ,G显带分析。结果 :发现 2 3例染色体异常 ,占 6 7%,其中数目异常 4例 ( 17 3 9%) ,结构异常 16例 ( 69 5 7%) ,嵌合体 3例 ( 13 0 4%)。结论 :羊水细胞的染色体核型分析是染色体病产前诊断的确诊方法之一。

Objective To explore the use of amniocentesis in prenatal analysis,and reduce the newborn with abnormal chromosome.Methods Amniocentesis was employed to detect amniotic cells collected from 342 pregnant women with high-risk prenatal diagnosis indications.Results It was shown by karyotype analysis that 23 cases(6.7%) were found with abnormal karyotype,in which 4 cases(17.89%) were found with abnormal numbers,16 cases(69.57%) were found with abnormal construction,and 3 case(3.04%) were somatic mosaicism.Conclusions It is indicated that amniocentesis and karyotyping is one of the most important methods for prenatal diagnosis. [