脉冲振荡技术在儿童支气管舒张试验中的应用

The use of impulse oscillometry technique in children bronchial dilation test

目的 :探讨脉冲振荡方法 (IOS)在儿童支气管舒张试验中的应用及其与常规肺量计法结果的相关关系。方法 :发作期的哮喘患儿同时应用两种方法做吸入支气管扩张剂前后肺功能测定 ,以FEV1改善≥ 15 %判断为阳性 ,应用统计学处理对两种方法各指标作相关性分析。结果 :IOS各指标舒张后改善明显 ,△Zrs、△R5与金标准△FEV1密切相关 ,经多元回归得出方程△FEV1=- 1.5 2 7△Zrs +0 .883△R5。结论 :IOS法可以作为不能配合用力呼气动作的儿童行支气管舒张试验。

Objective: To investigate the use of IOS technique in bronchial dilation test, and assess the correlation between the impedance measured by IOS and FEV1 measured by spirometry in bronchial dilation test.Method: The impedance measured by IOS was compared with concomitant maximal expiratory flow-volume (MEFV) curve by spirometry during the bronchial dilation test in acute asthmatic children. The change of FEV1≥15% after inhaled bronchial dilator was considered positive. Statistical analysis was performed by using Pearson correlation and multiple linear regression, P values <0.05 were considerd significant.Result: There was significant decreasing of the impedance after inhaled the bronchial dilator. The changes of impedance parameters were significantly correlated with the change of FEV1, especially R5 and Zrs. By the analysis of multiple linear regression, we obtained the equation: △FEV1=-1.527△Zrs+0.883△R5.Conclusion: IOS may be used in bronchial dilation test in children.