糖尿病患者尿转化生长因子β1检测的临床意义

Clinical significance of Urinary transforming growth factor-β1 measurement in diabetics

目的 探讨转化生长因子 β1(TGF β1)在糖尿病肾病早期诊断和判断病变严重程度中的临床价值。方法 采用酶联免疫吸附法 (ELISA)检测 70例 2型糖尿病患者和 2 0例正常人尿TGF β1。同时检测尿视黄醇结合蛋白、尿白蛋白、血糖、血肌酐等。结果 糖尿病患者尿TGF β1排泄较正常对照组增高 ,在正常蛋白尿时已经升高 ,并且随肾脏病情加重进一步增高 ;糖尿病组尿RBP排泄较正常对照组升高 ;尿TGF β1与视黄醇结合蛋白呈正相关。 结论 检测尿TGF β1对早期发现糖尿病肾病和监测其进展具有重要意义。

Objective To investigate the clinical value of transforming growth factor beta-1(TGF-β1) in diagnosis and severity assessment of diabetic nephropathy. Methods TGF-β1 was detected Using ELISA method in 70 patients with type 2 diabetes and 20 controls. Urinary retinal-binding protein(URBP) and urinary albumnin excretion rate(UAER) were also measured simultaneously. Results Urinary TGF-β1 levels significantly increased in diabetic patients even without obvious nephropathy compared with the controls(62.23±35.83) μg/mol vs (19.89±13.06) μg/mol,P<0.01) and furtherly increased as the nephropathy progressed. TGF-β1 was highly correlated with URBP which was significantly higher than in controls. Conclusion TGF-β1 might be an early marker for predicting diabetic nephropathy and assessing its severity.