胺碘酮加小剂量地高辛转复房颤32例报告

CONVERSION AND MAINTENANCE OF SINUS RHYTHM BY AMIODARONE AND SMALL DOSAGE DIGOXINE IN 32 PATIENTS WITH HYPERTENSIVE AND CORONARY HEART DISEASES AND ATRIAL FIBRILLATION

目的 观察可达龙 (胺碘酮 )加小剂量地高辛对部分经冠脉造影确诊的高血压性心脏病 (高心病 )与冠心病患者心房颤动 (房颤 )转复窦性心律的可能与安全性。方法 符合入选条件、住院连服 2周可达龙 (0 .2g,3/d)未复律的高心病、冠心病并房颤患者 32例 ,加服地高辛 0 .1 2 5g ,2 /d ,2周后为观察终点 ,判断其房颤转复成功率与用药安全性 ;并随访半年 ,观察房颤复发率。结果 32例中转复窦性心律 2 3例 ,转复率 71 .9% ,平均转复时间 (7± 2 )d ,无一例出现药物副作用 ;随访半年 ,复发 6例 ,复发率占复律者的 2 6 .1 %。结论 可达龙加小剂量地高辛对高心病、冠心病患者的房颤转复窦性心律 ,具有疗效较高 ,安全性与依从性好等优点 ,但仍有一定的复发率。

Objective To observe the conversion and maintenance of sinus rhythm by amiodarone and small dosage digoxine in patients with hypertensive and coronary heart diseases and the therapy safty and compliance. Methods According to the selected conditions, 32 patients with hypertensive and coronary heart diseases and atrial fibrillation, who had being administered amiodarone (0.2, three times per day ) for two weeks and still had atrial fibrillation during their hospitalization, would be administered small dosage digoxine (0.125, twice per day) for two weeks. And then, the conversion and maintenance of sinus rhythm and the therapy safty would be observed. All of the patients would be followed up in half a year. Results Atrial fibrillation was convered to sinus rhythm in 23 (71.9 percent) of the 32 patients, the mean time of conversion of sinus rhythm was (7±2) days. None of the patients had any side effects. 6 (26.1 percent) of the 23 patients had atrial fibrillation again within following up half a year. Conclusion Conversion of sinus rhythm by amiodarone and small dosage digoxine in the selected patients with hypertensive and coronary heart disease and atrial fibrillation have a higher successful rate, better safety and compliance. But after conversion, long-term maintenance of sinus rhythm by drugs in the patients maybe further studied.