鼻咽癌患者外周血淋巴细胞染色体畸变的研究

Study on the Chromosome Aberration of Peripheral Blood Lymphocytes in Patients with Nasopharyngeal Carcinoma

目的 探讨鼻咽癌患者淋巴细胞染色体畸变情况。方法 用 TC199培养基 ,对 2 8例鼻咽癌患者和2 0例正常人进行外周血淋巴细胞染色体畸变的检测。结果 鼻咽癌患者外周血淋巴细胞染色体数目、结构、畸变细胞率和微核率分别为 8.68%、10 .89%、8.65 %和 1.83 % ,均较正常人组有显著性差异 ( P<0 .0 1或 P<0 .0 5 ) ,畸变率明显高于正常人。

Objective To study the peripheral lymphocyte chromosome aberration in the patients with nasopharyngeal carcinoma. Methods The peripheral blood lymphocytes, from 28 patients with nasopharyngeal carcinoma and 20 normal controls were cultured with TC199 medium for this study on chromosome aberration. Results The chromosome number aberration rate, structure aberration rate, micronucleus rate and cell aberration rate of the peripheral lymphocytes from the patients with nasopharyngeal carcinoma were 8.68%, 10.89%, 1 83% and 8.65%, and these rates were significantly higher than those of normal controls, respectively (P<0.05 or P<0.01 ). Conclusion The above findings demonstrated the instability of chromosomes in the peripheral blood lymphocytes of nasopharyngeal carcinoma patients.