SO_2吸入对大鼠血压的影响

The Effects of Sulphur Dioxide Inhalation on the Blood Pressure of Rats

目的研究SO2吸入对大鼠血压的作用。方法采用SO2动态熏气技术使雄性Wistar大鼠染毒7d,SO2的染毒剂量分别为28.6、57.3、114.4mg/m3,通过RBP-1型大鼠血压计测量熏气期间大鼠每天的血压变化情况。结果28.6mg/m3SO2吸入的第3天和第4天引起大鼠血压降低,与其本底值相比差异有显著性(P<0.05);当SO2浓度为57.3mg/m3时,实验组大鼠血压下降,与其本底值相比,差异均有显著性(P<0.05或P<0.01),与对照组相比,第2天至第6天差异有显著性(P<0.05或P<0.01)。结论SO2吸入可引起大鼠血压降低,说明SO2可影响大鼠心血管系统的正常功能。

Objective To study the effects of sulphur dioxide(SO 2 )inhalation on the blood pressure of rats.Methods The male Wistar rats were exposed to28.6,57.3and114.4mg /m 3 SO 2 six hours each day for7days respectively by the tech-nique of dynamic fumigation and the ratsblood pressures were measured using RBP-1model blood pressure meter every day af-ter the SO 2 inhalation.Results28.6mg /m 3 SO 2 inhalation could cause a decrease of the ratsblood pressures compared with the background value at3rd and4th day(P<0.05).57.3mg /m 3 SO 2 inhalation led to the significant decrease,compared with the background value during the7-day exposure(P<0.05or P<0.01)and significant decrease compared with the control during the period from the2nd day to the6th day of the7-day exposure(P<0.05or P<0.01).Con clusion SO 2 inhalation could lower the blood pressure of rats,indicating that SO 2 might affect the functions of ratscardiovascular systems.