血浆同型半胱氨酸水平与重度妊高征的关系

Relationship between plasma homocysteine content and severe pregnancy-induced hypertension

目的 探讨血浆同型半胱氨酸 (HCY)与妊高征之间的关系。方法 采用高效液相色谱法测定重度妊高征患者及正常晚期妊娠妇女血浆HCY水平 ,同时用放射免疫法测定叶酸、维生素B12 含量 ,对两组患者HCY浓度、叶酸、维生素B12 进行比较。结果 妊高征组与对照组间叶酸、维生素B12 浓度无明显差异 (P >0 .0 5 ) ,而血浆HCY浓度妊高征组显著高于对照组 (P <0 .0 1)。结论 血浆中HCY浓度升高与妊高征关系密切 。

Objective To explore the relation between the pregnancy-induced hypertension (PIH) syndrome and the hyperhomocysteine (HCY) by measuring the content of the HCY in the patients with severe PIH. Methods The high- performance liquid chromatography was used to measure the level of the homocysteine in the plasma of PIH patients, which was compared with the control group (late pregnancy healthy women); the levels of folic acid and vitamin B 12 were measured by radioimmunoassay and the concentrations of HCY, folic acid and vitamin B 12 of the patients in two groups were compared.Results There was no obvious difference in folic acid, vitamin B 12 and the density between the patients in two groups (P>0.05);the average level of the HCY patients was significantly higher than that of the control group(P<0.01).Conclusion There is close correlation between the PIH and the hyperhomocysteine and the reason for raised HCY concentrations needs further study.