摘要
目的 探讨大白鼠心肌缺血及缺血再灌注的模型的最佳手术方法。方法 2 4只大鼠分成 4组 ,每组 6只 ,分别从胸部不同部位进入胸腔 ,结扎心脏冠状动脉左缘支 ,制备缺血模型。结果 从胸骨旁线、锁骨中线、第 2肋间隙部位进入胸腔的 3种手术方式极易造成大鼠死亡 ,从胸部的正中部位的手术方法较安全可靠。
Objective To investigate the most convenient and reliable methods for making ischemia and ischemia-reperfusion model of rat heart.Methods Thirty mature rats were divided into 5 groups, and 6 different surgical means were respectively used to enter pleural cavity randomly .Ischemia models were prepared by ligating left edge branch of coronary artery.Results The entrance to thoracic cavity from mid-thoracic line was safe and reliable, and the entrance from parasternal line,mid-clavieular and intercostal space Ⅱ often caused rat died.Conclusions The best surgical means of madding ischemia and ischemia-reperfusion model of rat heart was entering pleural cavity by mid-sternal incision.
出处
《新乡医学院学报》
CAS
2003年第4期260-261,共2页
Journal of Xinxiang Medical University
关键词
大白鼠
缺血
缺血再灌注
rat heart
ischemia
ischemia-reperfusion
